Nov. 13, 2023, 8:00 AM - 12:00 PM
PSTR185.02 - Characterization of VGF in the nucleus accumbens and its contribution to opioid-evoked behaviors Board B41
*A. P. ADKE1,2, S. M. MULLOY3, R. GAO4, A. M. LEE4, L. VULCHANOVA5, P. E. ROTHWELL5;
1Mol. Pharmacol. & Therapeut. Grad. Program, 2Med. Scientist Training Program, 3Grad. Program in Neurosci., 4Dept. of Pharmacol., 5Dept. of Neurosci., Univ. of Minnesota, Minneapolis, MN
PSTR207.07 - Targeting translaminar interneurons of the spinal cord dorsal horn for the study of somatosensory integration in chronic pain Board AA7
M. E. DOTY1, L. VULCHANOVA2, *A. G. J. SKORPUT3;
1Dartmouth Col., Hanover, NH; 2Univ. of Minnesota, Minneapolis, MN; 3Neurol., Dartmouth Hlth., Lebanon, NH
Nov. 13, 2023, 1:00 PM - 5:00 PM
PSTR253.24 - Agmatine modulates microglial activity in nucleus accumbens of fentanyl self-administration mice Board D9
*C. BARAJAS1, C. PETERSON2, K. F. KITTO1, G. L. WILCOX4, C. A. FAIRBANKS3;
2308 Harvard Street SE, 3Univ. of Minnesota, 1Univ. of Minnesota, Minneapolis, MN; 4Univ. Minnesota Med. Sch., Univ. Minnesota Med. Sch., Minneapolis, MN
PSTR270.05 - Decreased AC1 and increased SUR1 spinal cord expression attenuates opioid tolerance and withdrawal in mice Board Y4
*K. M. JOHNSON, B. A. MEYER, J. MELLANG, A. L. FOWLER, A. H. KLEIN;
Univ. of Minnesota, Duluth, MN
PSTR270.27 - Inhibition of adenylyl cyclase and exchange protein activated by cAMP enhances potassium flux in primary and immortal neuronal cell cultures Board Z7
*B. NELSON1, C. HILL1, A. H. KLEIN2;
2Univ. of Minnesota Duluth, 1Univ. of Minnesota, Duluth, MN
PSTR270.11 - Lysophosphatidic acid contributes to hyperalgesia in a humanized mouse model of sickle cell disease through direct sensitization of dorsal root ganglia neurons Board Y10
*V. VIATCHENKO-KARPINSKI1, M. JOHNS1, I. A. KHASABOVA1, S. G. KHASABOV1, K. GUPTA2, D. A. SIMONE1;
1Sch. of dentistry, Univ. of Minnesota, Twin Cities, Minneapolis, MN; 2Dept. of Med., Univ. of California, Irvine, CA
Nov. 14, 2023, 1:00 PM - 5:00 PM
PSTR410.10 - Single cell transcriptomic analysis of DNA methylation machinery in the prefrontal cortex of transient and persistent neuropathic pain mouse models Board AA4
*S. LEE1, M. RIEDL2, L. VULCHANOVA2, L. STONE1;
1Anesthesiol., 2Neurosci., Univ. of Minnesota, Minneapolis, MN
PSTR410.12 - Sexual dimorphism in the spinal effects of the VGF derived peptide TLQP-62 Board AA6
*T. XIE1, R. E. SCHORN2, E. MARRON FERNANDEZ DE VELASCO3, G. L. WILCOX4, C. A. FAIRBANKS5, L. VULCHANOVA2;
1Dept of Pharmaceutics, 2Dept of Neurosci., 3Dept of Pharmacol., 4Dept Neurosci, Pharmacol, Dermatol, 5Dept of Pharmaceutics, Pharmacology, Neurosci., Univ. of Minnesota, Minneapolis, MN
Nov. 15, 2023, 8:00 AM - 12:00 PM
PSTR477.13 - Agmatine-based analog inhibits spinal NMDAr-mediated EPSCs with apparent subunit selectivity Board BB22
*L. CAYE1, C. D. PETERSON2, C. A. FAIRBANKS3, G. L. WILCOX4;
1Pharmacol., 2Col. of Pharm., 3Pharmaceutics, Col. of Pharm., 4Neuroscience, Pharmacology, Dermatol., Univ. of Minnesota, Minneapolis, MN
PSTR477.16 - Development of agmatine-based NMDAr antagonists for the treatment of post-operative pain Board BB25
*C. PETERSON1, L. CAYE2, K. KITTO3, G. L. WILCOX4, C. FAIRBANKS1;
2Mol. Pharmacol. and Therapeut., 3Neurosci., 1Univ. of Minnesota, Minneapolis, MN; 4Dept Neurosci, Pharmacol, Dermatol, Univ. Minnesota Med. Sch., Minneapolis, MN
PSTR544.19 - Impact of chronic alcohol consumption on tactile hypersensitivity in models of persistent pain Board CC6
*R. E. SCHORN1,2, M. S. RIEDL2, L. S. STONE3, A. M. LEE2,4, L. VULCHANOVA2;
1Neurosci., Univ. of Minnesota Grad. Program In Neurosci., Minneapolis, MN; 2Neurosci., 3Anesthesiol., 4Pharmacol., Univ. of Minnesota, Minneapolis, MN
PSTR477.09 - Agmatine inhibits NMDA receptor-mediated calcium transients in spinal cord dorsal horn through nNOS attenuation. Board BB18
T. XIE1, R. E. SCHORN2, C. D. PETERSON1, K. F. KITTO2, G. L. WILCOX2, L. VULCHANOVA2, *C. A. FAIRBANKS3;
1Pharmaceutics, 2Neurosci., 3Pharmaceutics, Pharmacology, Neurosci., Univ. of Minnesota, Minneapolis, MN